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[ProImmune] CoVID-19/SARS-CoV-2 MHC Pentamers and Tetramers for tracking antigen-specific CD

관리자 2020.09.11 16:44 조회 1491 추천 29

Pro5® MHC Class I Pentamers

ProT2® MHC Class II Tetramers

rapidly growing product range for understanding CD8+ and CD4+ T cell responses to CoVID-19/SARS-CoV-2

ProImmune provided CoVID-19/SARS-CoV-2 Pro5® MHC Pentamers and peptides for the identification and characterization of SARS-CoV-2 specific T cell responses in convalescent patients, which has now resulted in the following key new early collaborative publication by an international team in China and the UK including Oxford University and ProImmune:

Peng Y., Dong T., et al. (2020) "Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19"

Nature Immunology (2020)

https://doi.org/10.1038/s41590-020-0782-6

 

Figure. Examples of peptide - MHC class I Pro5® MHC Pentamer staining ex vivo, with PBMCs (HLA-B*07:02/SPRWYFYYL, B*40:01/MEVTPSGTWL, A*11:01/KTFPPTEPK, A*01:01/FTSDYYQLY and A*02:01/YLQPRTFLL) or with cultured cell lines (HLA-A*0301/KTFPPTEPK). Datasets provided by Peng Y. from the study now published in Nature Immunology (2020).

 

Pro5® Pentamer

 

ProT2® Tetramer

The following product range of CoVID-19/SARS-CoV-2-specific Pro5® Pentamers and ProT2® Tetramers for a range of published CD8+ and CD4+ T cell epitopes is available ordering immediately.

 

CoVID-19/SARS-CoV-2-specific Pro5® Class I Pentamers

AllelePeptide CodePeptide SequenceEpitope Origin
A*01:014355FTSDYYQLYORF3a 207-215 (confirmed epitope)
A*01:014382PTDNYITTYReplicase polyprotein 1ab 1621-1629 (confirmed epitope)
A*01:014381TTDPSFLGRYReplicase polyprotein 1ab 1637-1646 (confirmed epitope)
A*02:014339YLQPRTFLLS protein 269-277 (confirmed immuno-dominant epitope)
A*02:014358RLQSLQTYVS protein 1000-1008 (confirmed subdominant epitope)
A*02:014320LLLDRLNQLN protein 223-231
A*02:014321FIAGLIAIVS protein precursor 1202-1210 (confirmed subdominant epitope)
A*02:014322ALNTLVKQLS protein precursor 940-948
A*02:014323LITGRLQSLS protein precursor 978-986 (confirmed subdominant epitope)
A*02:014324NLNESLIDLS protein precursor 1174-1182
A*02:014326VLNDILSRLS protein precursor 958-966
A*02:014339YLQPRTFLLSpike glycoprotein 269-277 (confirmed epitope)
A*02:014342LLYDANYFLORF3a 139-147 (confirmed epitope)
A*02:014358RLQSLQTYVSpike glycoprotein 1000-1008 (confirmed subdominant epitope)
A*02:014418KLWAQCVQLSARS-CoV-2 ORF1ab 3886-3894 (confirmed epitope)
A*03:014356AKTFPPTEPKN protein 362-370 (confirmed epitope)
A*11:014356BKTFPPTEPKN protein 362-370 (confirmed epitope)
B*07:024351SPRWYFYYLN protein 105-113 (confirmed epitope)
B*40:014328MEVTPSGTWLN protein 322-331 (confirmed immuno-dominant epitope)

 

CoVID-19/SARS-CoV-2-specific ProT2® Class II Tetramers

AllelePeptide CodePeptide SequenceEpitope Origin
DRB1*01:014329GAALQIPFAMQMAYRFS protein 873-888
DRB1*01:014330MAYRFNGIGVTQNVLYS protein 884-899
DRB1*01:014331AQLIRAAEIRASANLAATKS protein 993-1010
DRB1*04:014332QALNTLVKQLSSNFGAIS protein 939-955
DRB1*04:014331BQLIRAAEIRASANLAATKS protein 993-1010

 

Order CoVID-19/SARS-CoV-2 Pro5® Pentamers

Order CoVID-19/SARS-CoV-2 ProT2® Tetramers

 

More on Pro5® Class I MHC Pentamers

More on ProT2® Class II MHC Tetramers

 

 

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