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[iba GmbH] CD3/CD28 Streptamer® Kit, human - Poppular Product

관리자 2021.05.13 10:18 조회 931 추천 21

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CD3/CD28 Streptamer® Kit, human



    T cell activation and expansion with removable stimulation reagents    







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Description

The CD3/CD28 Streptamer® approach is based on our Strep-tag® technology and facilitates T cell 
activation and expansion. Low affinity Fab fragments fused to a Twin-Strep-tag® (Fab-Streps) 
against CD3 and CD28 are multimerized on a Strep-Tactin® multimer backbone. The resulting 
CD3/CD28 Streptamer® complex stimulates the T cell receptor/CD3 complex 
(TCR/CD3; signal 1) and the co-stimulatory molecule CD28 (signal 2). Providing these two signals leads 
to efficient T cell activation  and proliferation. For in vitro stimulation and activation, the soluble 
CD3/CD28 Streptamers are added to T cells. The addition of biotin reverses the multimerization and 
causes the dissociation of low affinity Fab fragments from the cells. Consequently, the termination of 
stimulation is possible at any point in time.


Advantages

• Reversible reagents due to low affinity Fab fragments
• Accurately defined termination of stimulation


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Contents

Capacity:  Reagents for 5 x 10^7 total cells



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