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Protein purifications

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iba

For more than two decades IBA provides innovative technologies for life science applications. The product portfolio includes tools for cell selection & expansion, protein production & assays as well as custom oligos & predefined DNA/RNA.

www.iba-lifesciences.com

Cell selection & expansion

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Automated cell selection via the Fab-TACS® technology directly from whole blood is possible using IBA’s design award winning FABian® device. Customized protocols depending on the cell type, the sample volume and the intended yield for the cell type of interest allow a convenient fully automatic cell isolation. Strep-tagged Fab fragments (Fab-Streps®) reversibly capture and release the target cells during the selection process. This delivers label-free, non-activated target cells in a standardized manner of highly reproducible quality. Isolated cells are suitable for all further immunologic or cell biologic investigations including cell based diagnostics or assays, e.g. pharmacological analysis of drug levels in the isolated cell fraction. Alternatively to FABian® we offer gravity flow columns for manual cells selection based on the same technology. For T cell stimulation, we offer completely novel reversible reagents, the Streptamers® for cell expansion, which provide unique flexibility for cell research.

Protein production & assays

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The Strep-tag® technology is IBA's proprietary and versatile protein purification, detection and immobilization platform. It is one of the most widely used systems for affinity purification that provides exceptional pure proteins. Recently the third generation of the Strep-tag system was launched based on the new Strep-Tactin®XT and Twin-Strep-tag®. Strep-Tactin®XT is a further developed Strep-Tactin® with extra tight binding to Twin-Strep-tag® now enabling the usage of the Strep-tag® technology in applications where extra tight binding is a requirement. Thereby the third generation Strep-tag® technology now enters the field of assay development and screening. This opens new possibilities in the pharmaceutical and biotech sector for, e.g. screening of new diagnostic targets and the development of diagnostic assays.

Custom Oligos & Predefined DNA/RNA

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IBA’s nucleic acid division has a focus on specialized nucleic acid custom services. The tailor-made DNA and RNA oligonucleotides, including modified and labeled nucleic acids, require particular care in synthesis and are of the highest quality. Applications can be found in e.g. real-time PCR, FRET, gene silencing studies, immobilization, FCCS or high resolution microscopy. The innovative Click Chemistry enables additional dye combinations with unsurpassed labeling densities. More than 200 fluorescent labels and more than 80 modifications are available. With our expertise, we can also produce custom DNA and RNA aptamers according to your individual specifications