β-Synuclein
- the Forgotten Synuclein, Or Is It?
Dear Researcher,
Synaptic loss, or the degeneration of synapses, is known to be one of
the hallmarks of Alzheimer’s Disease (AD) (Jackson
et
al.,
2019).
β-synuclein, a member of the synuclein family of proteins, is found in
abundance in presynaptic terminals. Unlike α-synuclein and sometimes
overlooked, recent research suggests β-synuclein to be an early diagnostic
marker for AD in CSF (Halbgebauer
et
al.,
2020).
NEW β-Synuclein Antibodies to
Advance your Research
Biosensis
has introduced two antibodies to β-synuclein, made in mouse
and rabbit.
Both antibodies are an excellent choice for use in Immunohistochemistry and
Western Blotting, complementing our well-established sheep
antibody to β-synuclein. Our β-synuclein antibodies
provide maximum flexibility in experimental design and high-quality results in
human and rodent samples.
Analysis
of β-synuclein expression in rat cerebellum section
by Immunohistochemistry. β-synuclein (red) was detected with rabbit
antibody R-2105-100
(1:1,000), and sections co-stained with chicken antibody to parvalbumin (C-1814-50,
green, 1:5,000). Blue: Hoechst nuclear stain. The β-synuclein antibody
detects protein concentrated in synaptic regions, while the parvalbumin
antibody labels the perikarya
and dendrites of Purkinje cells and interneurons in the molecular layer of the
cerebellum.
Western blot analysis of
β-synuclein expression in tissue homogenates using mouse antibody M-2106-100
(green, 1:1,000). Lane 1: MWM; Lane 2: rat cortex; Lane 3: rat cerebellum; Lane
4: mouse cortex; Lane 5: mouse cerebellum; Lane 6: cow cortex; Lane 7: cow
cerebellum. A strong band at about 17 kDa
corresponds to β-synuclein protein.
(주)엘바이오시스템은 biosensis의 한국공식대리점입니다. 제품의 주문 및 관련정보가 필요하시면 전화, 팩스, 이메일로 문의해 주세요.
