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[CD Bioparticles] Fluorescent silica particles

관리자 2023.02.15 14:13 조회 831 추천 15
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CD Bioparticles provides silica particles with a high 
amount of covalently bound fluorescence dye 
in the silica matrix. 

CD Bioparticles provides silica particles with a high amount of covalently bound fluorescence dye in the silica matrix. The fluorescent silica particles we offer consist of ultra-monodisperse spherical silica particles loaded with a fluorescent dye, providing fluorescence capabilities comparable to heavy metal quantum dots (which are generally classified as toxic), with excitation/emission values dependent on the dye/color. Dye-doped silica particles allow different dyes and drugs to be accommodated in the silica matrix while still allowing control over the resulting particle size and shape. Furthermore, their adaptable and well-understood chemistry allows simple and straightforward modifications of particle surface chemistry, providing reactive sites for further functionalization.


Currently, fluorescent silica particles have been widely used in biology and biomedicine as a potential fluorescent probe. Various biomedically important targets, such as cancer cells, bacteria, and individual biomolecules, could be labeled with highly fluorescent silica particles. With excellent fluorescence properties, silica particles with various fluorescence and functional groups we provide can be used in many fields, such as biomarkers, biological imaging, and biosensing.



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Delivering therapeutic microRNA with silica nanoparticles for cancer therapy.

The NPs contained a NIR dye as a contrast reagent and were loaded with therapeutic miRNA34-a.
Adapted from Gubala, 2020.


The fluorescent silica nanoparticles are available with red fluorescence (excitation: 569 nm, emission: 585 nm), green fluorescence (excitation: 485 nm, emission: 510 nm) and blue fluorescence (excitation: 354 nm, emission: 450 nm). Different surface functionalities including Si-OH, NH2 and COOH enable covalent binding of proteins, antibodies, oligonucleotides, and other molecules.


Available with Red Fluorescent Silica Nanoparticles with different functional groups, including Hydroxyl, AmineBisphosphonate AlendronateCarboxylOctadecyl (C18), and PEG 2000.
Available with Red Fluorescent Silica Particles with different surfaces, including HydroxylAmineCarboxyl, and Streptavidin.
Available with Green Fluorescent Silica Nanoparticles with different functional groups, including HydroxylAmineAvidin and Carboxyl.
Available with Green Fluorescent Silica Particles with different functional groups, including HydroxylAmineCarboxylNi-NTANR3+,and Octadecyl (C18).
Available with Blue Fluorescent Silica Nanoparticles with Hydroxyl functional group.
Available with Blue Fluorescent Silica Particles with different functional groups, including HydroxylAmine, and Carboxyl.
Available with NIR Fluorescent Silica Nanoparticles with Hydroxyl functional group.

Applications

The fluorescent silica particles from CD Bioparticles can be used in a variety of applications. Examples of common applications are below.

Fluorescent imaging and multimodal imaging
Drug and gene delivery
Immunoassays and biosensors
Theranostic platform
Disease treatment

Reference

Gubala, V.; et al. Dye-doped silica nanoparticles: synthesis, surface chemistry and bioapplicationsCancer Nanotechnology, 2020, 11(1): 1-43.



Select a product tile below to learn more & buy

    

Cat. No.

Description

Diameter

Surface

DNG-L039

Red Fluorescent Silica Particles

20 μm

Hydroxyl

DNG-L040

Green Fluorescent Silica Particles

20 μm

Hydroxyl

DNG-L078

Red Fluorescent Silica Particles

20 μm

Amine

DNG-L079

Green Fluorescent Silica Particles

20 μm

Amine

DNG-L080

Blue Fluorescent Silica Particles

20 μm

Carboxyl

DNG-L118

Red Fluorescent Silica Particles

20 μm

Carboxyl

DNG-L119

Green Fluorescent Silica Particles

20 μm

Carboxyl

DNG-L120

Blue Fluorescent Silica Particles

20 μm

Carboxyl

DNG-L037

Green Fluorescent Silica Particles

15 μm

Hydroxyl

DNG-L038

Red Fluorescent Silica Particles

15 μm

Hydroxyl

DNG-L075

Green Fluorescent Silica Particles

15 μm

Amine

DNG-L076

Blue Fluorescent Silica Particles

15 μm

Amine

DNG-L077

Red Fluorescent Silica Particles

15 μm

Amine

DNG-L115

Green Fluorescent Silica Particles

15 μm

Carboxyl

DNG-L116

Blue Fluorescent Silica Particles

15 μm

Carboxyl

DNG-L117

Red Fluorescent Silica Particles

15 μm

Carboxyl

DNG-L035

Green Fluorescent Silica Particles

10 μm

Hydroxyl

DNG-L036

Red Fluorescent Silica Particles

10 μm

Hydroxyl

DNG-L072

Green Fluorescent Silica Particles

10 μm

Amine

DNG-L073

Blue Fluorescent Silica Particles

10 μm

Amine





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