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NEW RELEASED KIT!
A validated ELISA for Glutamine quantification
Glutamine (Gln) is an abundant non-essential amino acid that is involved in several physiological functions including the regulation of the immune system (1). However, in some disease conditions, Gln metabolism can be highly dysregulated. In cancer, Gln is highly consumed by tumor cells as to fulfill their bioenergetic and biosynthetic requirements for proliferation (2). Targeting Gln catabolism - mainly Glutaminase - is currently investigated as a therapeutic approach to circumvent high Gln consumption by cancer cells and maintain a sufficient level in the microenvironment for an effective anti-tumor immune response (3).
For a quantitative determination of Gln in preclinical or clinical plasma / serum samples, we developed and validated a novel ELISA kit (#IS-I-1100) requiring a sample volume as low as 10μL and characterized by a 3µM sensitivity.
Sensitive & easy-to-implement
Typical standard curve obtained with the Gln ELISA (#IS-I-1100) kit where the optical density is inversely correlated with Gln concentration within a linear range of 21 - 3125μM.
Cross-validated with LC/MS
Gln was quantified in human plasma samples from 40 healthy subjects using IS-I-1100 ELISA kit and by LC/MS. Correlation between both methods gave a R-squared value above 0.99, thereby confirming the accuracy of the immunoassay.
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