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[alomone labs] Of Mitochondria and Stiff Hearts

관리자 2023.08.14 15:04 조회 530 추천 2
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Of Mitochondria and Stiff Hearts



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Hypertrophic cardiomyopathy (HCM) is the leading cause of sudden cardiac death in the 5–15 age bracket. HCM primarily occurs because mutations in cardiac sarcomeres render the heart stiff and overactive. New work using a novel in vitro model of cardiac stiffening establishes an intriguing link between L-type calcium channels and mitochondria.



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New Products


Membrane Protein Immunodetection


Primary Antibodies:


Guinea pig Anti-D1 Dopamine Receptor Antibody

Cat #: ADR-001-GP
Type: Polyclonal | Host: Guinea pig | Applications: IF, IHC, WB, *ICC, *IFC, *IP |

Reactivity: H, M, R


Anti-RIM1 Antibody

Cat #: AIP-014
Type: Polyclonal | Host: Rabbit | Applications: WB, *ICC, *IFC, *IHC, *IP  |

Reactivity: M, R, *H


Anti-ZnT1 (SLC30A1) Antibody

Cat #: AZT-011
Type: Polyclonal | Host: Rabbit | Applications: IF, IHC, WB, *ICC, *IFC, *IP  |

Reactivity: M, R, *H


Anti-EMR1 (ADGRE1) (extracellular) Antibody

Cat #: #AER-051
Type: Polyclonal | Host: Rabbit | Applications: ICC, IF, IFC, LCI, WB, *IHC, *IP | 

Reactivity: H, M, R



Antibodies for Live Cell Direct Flow Cytometry:

Anti-Calcium Sensing Receptor (extracellular)-FITC Antibody

Cat #: ACR-004-F
Type: Polyclonal | Host: Rabbit | Applications: FC, LCI, *ICC | Reactivity: H, M, R


Anti-D2 Dopamine Receptor (extracellular)-FITC Antibody

Cat #: ADR-002-F
Type: Polyclonal | Host: Rabbit | Applications: FC, LCI, *ICC | Reactivity: H, M, R


 

Ion Channel Pharmacology


Small Organic Molecules:

Pyrrolopyrimidine 48

Cat #: P-275
Type: Small Molecules | SourceSynthetic | MW: 385.46 |

Target: NaV1.7, NaV1.5 channels


NS-11021

Cat #: N-335
Type: Small Molecules | SourceSynthetic | MW: 511.24 |

Target: KCa1.1, KCNQ4 channels


TCN 201

Cat #: T-190
Type: Small Molecules | SourceSynthetic | MW: 461.89 | 

Target: NMDA receptors



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