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Delta,
Kappa, and Lambda SARS-CoV-2 Pseudotyped Lentivirus Now Available
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SARS-CoV-2 pseudotyped lentivirus is replication-incompetent
with safe (BSL-2), easy, and high-throughput viral infectivity and can be
used in neutralization assays with standard detection instrumentation. It
displays an antigenically correct spike protein on a heterologous virus
core and carries a modified genome that expresses a convenient optical
reporter gene (GFP or luciferase).
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Creative Diagnostics has a full range of ready-to-use wild-type
and newly emerged mutant SARS-CoV-2 pseudotyped lentiviruses to support the
study of the interaction between SARS-CoV-2 spike protein and human ACE2 in
a physiologically relevant context.
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Variants of Concern—AVAILABLE NOW
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Cat. No. (GFP/Luc Reporter)
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SARS-CoV-2 / Variant
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WHO
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Mutations
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COV-PS02/COV-PS01
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Wuhan-Hu-1
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———
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Reference
seq (GenBank QHD43416.1)
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COVG-B1617/COVL-B1617
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Indian
variant B.1.617, RBD mutations only (“double mutant”)
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———
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L452R,
E484Q, D614G
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COVG-KA1/COVL-KA1
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Indian
variant B.1.617.1
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Kappa
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G142D,
E154K, L452R, E484Q, D614G, P681R, Q1071H
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COVG-DE2/COVL-DE2
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Indian
variant B.1.617.2
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Delta
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T19R, G142D,
del156/157, R158G, L452R, T478K, D614G, P681R, D950N
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COVG-DE417/COVL-DE417
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DELTA PLUS
(Delta + K417N) B.1.617.2.1
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———
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T19R, G142D,
del156-157, R158G, K417N, L452R, T478K, D614G, P681R, D950N
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COVG-LA37/COVL-LA37
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C.37
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Lambda
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G75V, T76I,
R246N, del247-253, L452Q, F490S, D614G, T859N
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COVG-ZE2/COVL-ZE2
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Brazilian
variant P.2
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Zeta
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E484K,
V1176F, D614G
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COVG-JBV1/COVL-JBV1
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Brazilian
variant P.1, 20J/501Y.V3
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Gamma
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ΔH69/V70,
ΔY144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H
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COVG-501YV2/COVL-501YV2
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South
African variant B.1.351, 20C/501Y.V2
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L18F, D80A,
D215G, L242H, R246I, K417N, N501Y, E484K, D614G, A701V
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COVG-BE1/COVL-BE1
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South
African variant Δ3 B.1.351, 20H/501Y.V2
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Beta
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L18F, D80A,
D215G, ΔL242/A243/L244, R246I, K417N, N501Y, E484K, D614G, A701V
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Features
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Pseudotyping
is available with wild type or mutant spike proteins from a wide range of
coronavirus species
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Safe to be
used in BSL-2 labs
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Unlimited
customization options including the addition of reporter genes for
monitoring viral entry
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Quality-controlled
production for use as a critical reagent
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