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[Creative Diagnostics] Delta, Kappa, and Lambda SARS-CoV-2 Pseudotyped Lentivirus Now Available

관리자 2021.08.23 10:03 조회 290 추천 6

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Delta, Kappa, and Lambda SARS-CoV-2 Pseudotyped Lentivirus Now Available

SARS-CoV-2 pseudotyped lentivirus is replication-incompetent with safe (BSL-2), easy, and high-throughput viral infectivity and can be used in neutralization assays with standard detection instrumentation. It displays an antigenically correct spike protein on a heterologous virus core and carries a modified genome that expresses a convenient optical reporter gene (GFP or luciferase).

Creative Diagnostics has a full range of ready-to-use wild-type and newly emerged mutant SARS-CoV-2 pseudotyped lentiviruses to support the study of the interaction between SARS-CoV-2 spike protein and human ACE2 in a physiologically relevant context.

Variants of Concern—AVAILABLE NOW

 

Cat. No. (GFP/Luc Reporter)

SARS-CoV-2 / Variant

WHO

Mutations

COV-PS02/COV-PS01

Wuhan-Hu-1

———

Reference seq (GenBank QHD43416.1)

COVG-B1617/COVL-B1617

Indian variant B.1.617, RBD mutations only (“double mutant”)

———

L452R, E484Q, D614G

COVG-KA1/COVL-KA1

Indian variant B.1.617.1

Kappa

G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H

COVG-DE2/COVL-DE2

Indian variant B.1.617.2

Delta

T19R, G142D, del156/157, R158G, L452R, T478K, D614G, P681R, D950N

COVG-DE417/COVL-DE417

DELTA PLUS (Delta + K417N) B.1.617.2.1

———

T19R, G142D, del156-157, R158G, K417N, L452R, T478K, D614G, P681R, D950N

COVG-LA37/COVL-LA37

C.37

Lambda

G75V, T76I, R246N, del247-253, L452Q, F490S, D614G, T859N

COVG-ZE2/COVL-ZE2

Brazilian variant P.2

Zeta

E484K, V1176F, D614G

COVG-JBV1/COVL-JBV1

Brazilian variant P.1, 20J/501Y.V3

Gamma

ΔH69/V70, ΔY144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H

COVG-501YV2/COVL-501YV2

South African variant B.1.351, 20C/501Y.V2

———

L18F, D80A, D215G, L242H, R246I, K417N, N501Y, E484K, D614G, A701V

COVG-BE1/COVL-BE1

South African variant Δ3 B.1.351, 20H/501Y.V2

Beta

L18F, D80A, D215G, ΔL242/A243/L244, R246I, K417N, N501Y, E484K, D614G, A701V

Features

Pseudotyping is available with wild type or mutant spike proteins from a wide range of coronavirus species

Safe to be used in BSL-2 labs

Unlimited customization options including the addition of reporter genes for monitoring viral entry

Quality-controlled production for use as a critical reagent






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