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[Creative Diagnostics] SARS-CoV-2 Pseudovirus Neutralization Assay for Scientific Research

관리자 2020.05.22 10:29 조회 26

Newsletter May, 2020
SARS-CoV-2 Pseudovirus
Neutralization Assay
SARS-CoV-2 pseudovirus neutralization assay has potential applications in the diagnosis, prophylaxis, and treatment of SARS-CoV-2.
SARS-CoV-2 has been shown to use angiotensin-converting enzyme 2 (ACE2), the same cell entry receptor as SARS-CoV. The pseudotype lentiviral particles encode firefly luciferase in their lentiviral vector genome. When their genome integrates after entry into cells, firefly luciferase expression and activity are proportional to the number of cells that were transduced. Therefore, this method could be used as an alternative for safely conducting serologic studies in a rapid response in assessing the threat posed by SARS-CoV-2.
At present, we have successfully developed a SARS-CoV-2 pseudovirus with HIV lentiviral vector. The Luciferase luminescence value reaches 106 RLU after the pseudovirus infection, which can meet the requirement for SARS-CoV-2 neutralization assay and screening of neutralization antibodies or serum.
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Pseudotyped Luciferase rSARS-CoV-2 Spike
Pseudotyped Luciferase rSARS-CoV-2 Spike is a replication-restricted, recombinant pseudotyped lentiviral particles containing SARS-CoV-2 spike protein. Because the infectivity of Pseudotyped Luciferase rSARS-CoV-2 is restricted to a single round of replication, the pseudotypes can be handled using BSL-2 containment practices.
Human ACE2 Stable Cell Line - HEK293T
This cell line is constructed by tranducing human angiotensin I converting enzyme 2 (ACE2) into HEK293T cells, followed by stable cell selection. HEK293T is derived from HEK293 and is commonly used in scientific research. HEK293T-human ACE2 cell line can be used for in vitro screening and characterization of drug candidates against SARS-CoV and SARS-Cov2
Bioreagents to Assist Your Research for COVID-19 Outbreak
We are following the changing circumstances closely after the World Health Organization declared the Coronavirus outbreak a pandemic. During this period of global uncertainty, we'd like to assure you that Creative Diagnostics is operating at its full capacity. Our online experts will respond to your orders and inquiries promptly as usual… Learn more
Human Coronaviruses

Human coronaviruses (HCoVs) are enveloped, single-stranded, positive-sense RNA viruses that belong to the Coronaviridae family. The seven identified HCoVs (HCoV-229E, HCoV-NL63, HCoV-HKU1, HCoV-OC43, MERS-CoV, SARS-CoV, and SARS-CoV-2) fall into two of the four genera: HCov-229E and HCov-NL63 belong to the alpha coronaviruses, and the other five belong to beta coronaviruses… Learn more

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