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[Immunostar] Alzheimer’s research antibodies

관리자 2023.12.06 13:58 조회 345 추천 1
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Alzheimer’s research antibodies


Alzheimer’s research antibodies play a significant role in helping scientists find solutions to this disease and other dementias that affect 47 million people worldwide and 5.3 million Americans, numbers that are expected to triple by 2050, according to the Alzheimer’s Association. As the baby boomers age, 28 million are expected to develop this disease, with costs rising to nearly a quarter of all Medicare spending in the United States.

Since Dr. Aloysius Alzheimer first described the disease in 1906, scientists have made remarkable progress in understanding how this disease affects the brain. Over a decade later, breakthroughs in understanding and treatments are providing hope for people with Alzheimer’s disease.

These ImmunoStar antibodies have proven records in Alzheimer’s research. Search our Publication’s database with the keyword “Alzheimer’s” to find hundreds of publications referencing these antibodies. See our customer Testimonials for comments from neuroscientists extolling the results and service they rely on from ImmunoStar. Our antibodies are stable, high-titer, and consistent from lot-to-lot to ensure successful staining at an excellent value.



ImmunoStar Antibodies Proven for Alzheimer’s Research


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#22940


Neuropeptide Y Antibody


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Description

Neuropeptide Y (NPY) is a member of a regulatory peptide family and has a marked sequence homology with pancreatic polypeptide (PP) and peptide YY (PYY), which are other members of the family.  NPY is widely expressed in the nervous system and has been shown to be differentially expressed in inhibitory interneurons in the hippocampus in degenerative disease, as a powerful vasoconstrictor in the periphery, and increased expression of NPY in the hypothalamus correlates with food intake.

In the rat central nervous system, immunohistochemistry has found NPY-like cell bodies in the cortex, caudate-putamen, hypothalamus (arcuate nucleus), hippocampus, anterior westolfactory bulb, nucleus accumbens, amygdaloid complex and periaqueductal grey. NPY-like fibers and terminals are detected in high numbers in the bed nucleus of the stria terminalis, the peri- and paraventricular regions of the hypothalamus and thalamus and in discrete hypothalamic nuclei, particularly the suprachiasmatic nucleus.

Westerns are not recommended for the Neuropeptide Y antibody since the protein is too small to detect in gel.

Photo Description: IHC image of neurons staining for neuropeptide Y in the rat cortex (above) and striatum (below). The tissue was fixed with 4% formaldehyde in phosphate buffer, before being removed and prepared for vibratome sectioning. Floating sections were incubated at RT in 10% goat serum in PBS, before standard IHC procedure. Primary antibody was incubated at 1:5000 for 48 hours, goat anti-rabbit secondary was subsequently added for 1 hour after washing with PBS. Light microscopy staining was achieved with standard biotin-streptavidin/HRP procedure and DAB chromogen.

The second image above entitled “C.” is NPY interneurons (RED) in mouse striatum, GREEN staining is GFP expressed by medium spiny neurons provided Alipi Naydenov, Neurobiology and Behavior, Stella Lab University of Washington (see review below).


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Host: Rabbit

Quantity / Volume:  100 µL

State: Lyophilized Whole Serum

Reacts With: Alpaca (Llama), Bird, Bubalus Bubalis (Water Buffalo), Bullfrog, Cat, Ewe, Ferret, Fish, Frog, Frog (Xenopus Laevis), Ground Squirrel, Guinea Pig, Hamster, Human,  Monkey, Mouse, Ovine (Sheep), Pig, Psetta Maxima (Flat Fish), Rat, Sheep, Snake, Tadpole, Toad, Turtle, Zebrafish

Availability: In Stock

Preabsorption Control: Available at Sigma Aldrich, Catalog # N3266

Alternate Names:  Pro-neuropeptide Y; Neuropeptide tyrosine; prepro-neuropeptide Y; PYY4, anti-NPY

Gene Symbol:  NPY



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