Diphtheria is caused primarily by toxigenic Corynebacterium diphtheriae strains and occasionally by toxigenic C. ulcerans and C. pseudotuberculosis strains. The acute respiratory infection caused by Diphtheria is generally characterized by local growth of the bacterium in the pharynx with pseudomembrane formation. Then, systemic dissemination of diphtheria toxin (DT) induces lesions in distant organs. Diphtheria toxin is an exotoxin produced by the pathogen that inhibits protein synthesis and causes cell death. The disease may remain manageable, but in more severe cases, lymph nodes in the neck may swell, making breathing and swallowing more difficult. Diphtheria can also lead to paralysis of the eyes, neck, throat, or respiratory muscles. The CDC recommends diphtheria vaccination for infants, children, teens, and adults.

 Creative Diagnostics has released new diphtheria vaccine-related products, including antibodies, antigens and ELISA kits. The development and testing of diphtheria vaccines has been enhanced using these reagents suitable for routine diagnosis of diphtheria and epidemiological surveys.

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