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[BroadPharm] Click Chemistry in Alzheimer's and a New Technique in making ADCs!

관리자 2020.07.17 16:41 조회 144


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USC's Method with ADCs

A team at University of Southern California has engineered a faster way to effectively target malignant cells without damaging healthy tissue, which can help improve treatments for many different types of cancer. Current ADCs (antibody-drug conjugates) are made using a process with limited stability and efficacy. Homogeneous ADCs have a higher potential for clinical effectiveness, but still require long reaction times or multiple steps as well as trigger immune responses that can inhibit their functions. USC's potential solutions can allow homogeneous ADCs to use a single-step reaction in less than two hours compared to current processes. Their technology consists of a ‘linker’ recognized by a human enzyme that is able to “catalyze the conjugation of drug molecules to the antibodies at a defined position” according to USC’s assistant professor Yong (Tiger) Zhang. They have claimed that their method has a more safe and quick release of drugs into targeted cells. Read about it here

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Using Click Chemistry in Alzheimer's Disease

Excess copper from Alzheimer's disease can be removed using a synthesized drug that also photo-oxygenates amyloid-β plaques. Click Chemistry has been a potential option for this process. "Copper in amyloid-β–copper aggregates can catalyze an azide–alkyne cycloaddition – the classic click reaction – to turn the contents of the silica nanoparticles into a therapeutic compound." Read about it here 

Here at BroadPharm, we provide a variety of Click Chemistry tools. You can check them out here.


You can also contact us for inquiries on custom synthesis projects. We would love to contribute to your research and discovery.