chart a new path with next-generation binding reagents beyond antibodies
A new era of target-binding reagents beyond antibodies
next-generation target binding reagents provided by ProImmune that overcome
many of the current constraints of research antibodies. They offer affordable
high-quality customized recombinant monoclonal binding reagents for any
application and protein target.
Ankyrons disconnect from
the animal-immune response paradigm of antibodies as binding reagents.
All Ankyrons are based on
single domain ankyrin-repeat scaffold, selected in vitro by ribosome
display for medium to high affinity from ProImmune’s synthetic Ankyron
Teralibrary™ of around one billion (~1012) clones. Therefore
Ankyrons™ are by default recombinant sequence defined target binding molecules,
unlike standard monoclonal antibodies. The exceptionally large starting clone
number in our Teralibrary™ makes selecting Ankyrons more efficient than selecting
antibody fragments from comparable antibody screening libraries in vitro.
Figure 1: Domain comparison between Ankyons and
are highly stable recombinant single-domain binders. They can be directly
labelled or detected via an epitope or biotin tag. Ankyrons can be engineered
to combine them with further Ankyron or other domains much more easily than
even recombinant Antibodies. Unlike Antibodies, Ankyrons do not have isotypes
or any species origin.
- - Always
recombinant, monoclonal, sequence defined by default
- - Selected
entirely in vitro from our Teralibrary™ for higher affinity
- - Unconstrained
by immunological tolerance
- - Superior
single domain properties compared to antibodies
- - Fast,
inexpensive, customization with affinity tags and labels for every order
- - Rapidly
growing catalog range to very wide range of targets and target areas
- - Custom
recombinant monoclonal generation for any budget*
- - Further
formatting to order as multi-specifics and multivalent molecules available
- - More
cost-effective than research antibody technology in every respect
- - Generated
without animal immunization
- - Distinguish
closely related proteins with Ankyron guided selection
- - For
research applications, including: flow cytometry, ELISA, western blotting,
immunohistochemistry, immunoprecipitation, cell culture and more
You will be able to get Ankyrons for almost any target
with and label, custom-configured every time with a plethora of formatting and
customization options, including for bi-and multi-specific molecules, combined
with a full range of labeling options, covering most types of available
fluorochromes and other labels.
Below are some examples for Ankyrons selected for
otherwise challenging applications:
MHC-Peptide Specific Ankyrons
Detecting and targeting specific MHC-peptide complexes
is of material interest for understanding many disease conditions better and
for developing novel therapeutic interventions. It has been very challenging to
develop antibodies that bind selectively to an MHC-peptide combination over a
more general MHC allotype.
Below is our list of currently available MHC-peptide
If the specificity you want is
not on this list, we can always select it for you.
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