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[Biosensis] Biosensis Oligomeric Amyloid-Beta ELISA Kit

관리자 2024.06.05 11:14 조회 120 추천 1

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Oligomeric Amyloid-Beta ELISA Kit

A tool for advancing Alzheimer's studies


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Beta-amyloid protein (brown) in the Alzheimer’s affected brain. Image credits: NIH Image Gallery (CC BY-NC 2.0)




Oligomeric Amyloid-Beta as a Biomarker


Alzheimer's disease is intricately associated with the oligomeric form of amyloid-beta peptide (Aβ), particularly the variant Aβ, 1-42. Despite the development of several Enzyme-Linked Immunosorbent Assays (ELISAs) targeting Aβ, these assays commonly exhibit cross-reactivity with amyloid-beta precursor protein (APP) and demonstrate inefficacy in discerning between monomeric and oligomeric forms of the Aβ peptide.


In response to these challenges, Biosensis introduced an oligomeric Aβ ELISA kit (BEK-2215-1P/2P), a sandwich ELISA designed to enable the preferential quantification of oligomeric Aβ peptides. This kit comprises a pre-coated mouse monoclonal anti-Aβ capture antibody (MOAB-2), a biotinylated MOAB-2 detection antibody, and horseradish peroxidase (HRP)-conjugated streptavidin to measure Aβ levels accurately in both sample specimens and protein standards.



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A standard curve generated in our laboratory using oligomeric amyloid-beta ELISA kit (BEK-2215-1P/2P)



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ELISA test data using Biosensis' 2215 Oligomeric Abeta ELISA assay shows that it detects signals only from oligomeric clusters due to the unique N-terminal epitope of the MOAB-2 antibody. Biosensis has an exclusive license for MOAB-2 in immunoassays.



Citations of Our Product in the Leading Journals


Valencia-Olvera AC et al. (2023) Alzheimers Res Ther. 15(1):216Application: Mouse, TBS brain homogenates.

Kasus-Jacobi A et al. (2022) Biomolecules. 12, 1386. Application: Human, Aβ1–42 oligomers.

 

Eid A et al. (2022) Environ Health Perspect. Application: Mouse, brain tissue homogenate.

 

Kasus-Jacobi A et al. (2021) Curr Alzheimer Res. 18(5):414-427. Application: Mouse in-vitro assay, cell culture supernatant.

 

Hark TJ et al. (2020) Cell Syst.  Application: Mouse cortical homogenates.

 

Xiao L et al. (2020) Neural Regen Res. 15(12): 2270-2. Application: Rat PC12 RIPA cell extract.

 

Hrynchak MV et al. (2020) Front Synaptic Neurosci. Apr 24;12:16. Application: Mouse lysate.

 

El-Sayed NA et al. (2019) Bioorg Chem.  Application: Human. In-vitro screening of drug candidates.

 

Oh Joo Kweon et al. (2019) J Neurol Sci. Application: Human serum.


 




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