Oligomeric Amyloid-Beta ELISA Kit
A tool for advancing Alzheimer's
studies
Beta-amyloid protein
(brown) in the Alzheimer’s affected brain. Image credits: NIH Image
Gallery (CC BY-NC 2.0)
Oligomeric Amyloid-Beta as a
Biomarker
Alzheimer's
disease is intricately associated with the oligomeric form of amyloid-beta
peptide (Aβ), particularly the variant Aβ, 1-42. Despite
the development of several Enzyme-Linked Immunosorbent Assays (ELISAs)
targeting Aβ, these assays commonly exhibit cross-reactivity with amyloid-beta
precursor protein (APP) and demonstrate inefficacy in discerning between
monomeric and oligomeric forms of the Aβ peptide.
In response to these challenges, Biosensis
introduced an oligomeric Aβ ELISA kit (BEK-2215-1P/2P),
a sandwich ELISA designed to enable the preferential quantification of
oligomeric Aβ peptides. This kit comprises a pre-coated mouse monoclonal
anti-Aβ capture antibody (MOAB-2), a biotinylated MOAB-2 detection antibody,
and horseradish peroxidase (HRP)-conjugated streptavidin to measure Aβ levels
accurately in both sample specimens and protein standards.
A standard curve generated in our
laboratory using oligomeric amyloid-beta ELISA kit (BEK-2215-1P/2P)
ELISA test data using Biosensis'
2215 Oligomeric Abeta
ELISA assay shows that it detects signals only from oligomeric clusters due to
the unique N-terminal epitope of the MOAB-2 antibody. Biosensis
has an exclusive license for MOAB-2 in immunoassays.
Citations of Our Product in the
Leading Journals
Valencia-Olvera AC et al. (2023) Alzheimers
Res Ther.
15(1):216. Application: Mouse, TBS brain
homogenates.
Kasus-Jacobi
A et al. (2022) Biomolecules.
12, 1386. Application: Human,
Aβ1–42 oligomers.
Eid A et al. (2022) Environ
Health Perspect. Application: Mouse, brain
tissue homogenate.
Kasus-Jacobi
A et al. (2021) Curr
Alzheimer Res. 18(5):414-427. Application: Mouse in-vitro assay, cell culture
supernatant.
Hark TJ et
al. (2020) Cell
Syst.
Application: Mouse
cortical homogenates.
Xiao L et
al. (2020) Neural
Regen Res. 15(12): 2270-2. Application: Rat
PC12 RIPA cell extract.
Hrynchak
MV et
al. (2020) Front
Synaptic Neurosci.
Apr 24;12:16. Application: Mouse
lysate.
El-Sayed NA et
al. (2019) Bioorg
Chem.
Application: Human. In-vitro screening
of drug candidates.
Oh Joo Kweon et al. (2019) J
Neurol Sci.
Application: Human
serum.
Biosensis is a company that is
passionate about Science
